Mictamid 2.5% PAAG

is now Available to Licensed Veterinarians in the USA 

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Our Technology

Our hydrogels do not contain any additives, whether they be microparticles or products said to aid the anti-bacterial function of the gel, such as silver ions.  In each case, our hydrogel is effective and safe without these additives.
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Mictamid® is made up of 2.5% cross-linked polyacrylamide and 97.5% nonpyrogenic water.

2.5%PAAG Hydrogel

2.5% PAAG is different from other described hydrogels that have different concentrations of polyacrylamide and may contain other components as well, e.g. silver ions.  Furthermore, PAAG products, although often considered equal, have clear differences in composition, manufacturing and injection techniques as well as their ability to interact with surrounding tissues — characteristics that ultimately determine the safety and effectiveness of each hydrogel. 

Hydrogels are 3-dimensional, hydrophilic, polymeric networks capable of absorbing large amounts of water or biological fluids.  Due to their high water content, porosity, and soft consistency, they closely simulate natural living tissue. In addition to biocompatibility, 2.5% PAAG is shown to be long-lasting and nondegradable. 

Safety

2.5% PAAG has been studied for more than 30 years and found to be non-toxic, nonallergenic, nonteratogenic, nonembryotoxic, nonmutagenic, and nonbiodegradable.  2.5% PAAG has been proven safe in humans, horses, and dogs.

All studies are available by request.

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  3. Lose GMouritsen LNielsen JB. A new bulking agent (polyacrylamide hydrogel) for treating stress urinary incontinence in women  BJU Int.2006 Jul;98(1):100-4 https://www.ncbi.nlm.nih.gov/pubmed/16831152

  4. Lee SWSon YIKim CHLee JYKim SCKoh YW. Voice outcomes of polyacrylamide hydrogel injection LaryngoplastyLaryngoscope. 2007 Oct;117(10):1871-5 https://www.ncbi.nlm.nih.gov/pubmed/17690620

  5. Klarskov NLose G. Urethral injection therapy: what is the mechanism of action?
    Neurourol Urodyn.2008;27(8):789-92 https://www.ncbi.nlm.nih.gov/pubmed/18642372

  6. Narins RS and Schmidt R. Polyacrylamide hydrogel differences: Getting rid of the confusion. J Drugs Dermatol. 2011; 10(12): 1370-1375. https://jddonline.com/articles/dermatology/S1545961611P1370X/1/

  7. Imke Janssen, Marc Koene, Christoph Lischer. Intraarticular application of polyacrylamide hydrogel as a treatment of osteoarthritis in the distal interphalangeal joint: case series with 12 horses. 2012 Nov 28;650-656 https://www.researchgate.net/publication/285966771_Intraarticular_applikation_of_polyacrylamide_hydrogel_as_a_treatment_of_osteoarthritis_in_the_distal_interphalangeal_joint_Case_series_with_12_horses

  8. Sokol ERKarram MMDmochowski R. Efficacy and safety of polyacrylamide hydrogel for the treatment of female stress incontinence: a randomized, prospective, multicenter North American study. J Urol.2014 Sep;192(3):843-9 https://www.ncbi.nlm.nih.gov/pubmed/24704117

  9. Tnibar ASchougaard HCamitz LRasmussen JKoene M5, Jahn WMarkussen B. An international multi-centre prospective study on the efficacy of an intraarticular polyacrylamide hydrogel in horses with osteoarthritis: a 24 months follow-up. Acta Vet Scand. 2015 Apr 15;57:20 https://www.ncbi.nlm.nih.gov/pubmed/?term=An+international+multi-centre+prospective+study+on+the+efficacy+of+an+intraarticular+polyacrylamide+hydrogel+in+horses+with+osteoarthritis%3A+a+24+months+follow-up

  10. Calo E and Khutoryanskiy VV. Biomedical applications of hydrogels: A review of patents and commercial products. Eur Polym J. 2015; 65: 252-267. https://www.sciencedirect.com/science/article/pii/S0014305714004091

  11. Tnibar A, Persson AB, Jensen HE. Mechanisms of action of an intraarticular 2.5% polyacrylamide hydrogel (Arthramid Vet) in a goat model of osteoarthritis: Preliminary Observations. SM J Biomed Eng. 2017; 3: 1022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403890/

  12. Vallejo AGarcia-Ruano AAPinilla CCastellano MDeleyto EPerez-Cano R. Comparing efficacy and costs of four facial fillers in HIV-associated lipodystrophy: a clinical trial
    Plast Reconstr Surg.2017 Nov 8. https://www.ncbi.nlm.nih.gov/pubmed/29135895

  13. De Clifford LT, Lowe JN, McKellar CD, Chambers M, David F. A single site, double-blinded, prospective study on the comparative efficacy of a 2.5% polyacrylamide hydrogel in horses with inter-carpal joint lameness. Equine Vet J; [Online] 2019.  https://www.sciencedirect.com/science/article/abs/pii/S0737080618307615?dgcid=rss_sd_all

 

 
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